{"id":"W7132880340","doi":"","title":"Investigating the Impact of Genetics on the Effectiveness of Bupropion and Varenicline Treatment for Smoking Cessation","year":2024,"lang":"","type":"dissertation","venue":"TSpace","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Varenicline; Smoking cessation; Bupropion; Nicotine; Abstinence; Genome-wide association study; Nicotine dependence; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001901404,0.0002266411,0.0004960031,0.0003100412,0.0002373706,0.0005196425,0.0002707498,0.0005192571,0.00252915],"category_scores_gemma":[0.004147539,0.0001356736,0.001258548,0.0004292905,0.0001902453,0.0002148509,0.0002570158,0.0003547252,0.0002379309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005976184,"about_ca_system_score_gemma":0.0005955481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003807381,"about_ca_topic_score_gemma":0.006965293,"domain_scores_codex":[0.9988369,0.0005423265,0.00009636475,0.0002163811,0.0002151408,0.00009291103],"domain_scores_gemma":[0.9986274,0.0007365709,0.0003484415,0.00009038991,0.00009522063,0.0001019578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01190467,0.0006970635,0.8505558,0.0004574651,0.01121385,0.0002043403,0.0002239014,0.0003863932,0.009172349,0.0003335935,0.0008829896,0.1139677],"study_design_scores_gemma":[0.0004392243,0.003165738,0.9890105,0.00007047575,0.004628575,0.0001435603,0.00009697756,0.0004302297,0.0008314592,0.0002032785,0.0009715757,0.000008359578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929223,0.004844546,0.0003295809,0.0003226968,0.0000313732,0.00004515536,0.0005605365,0.00001086648,0.0009330061],"genre_scores_gemma":[0.9973568,0.001028143,0.0004052336,0.0002171829,0.00003442475,0.00003127658,0.0003931125,0.000007085735,0.0005266864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003807381,"threshold_uncertainty_score":0.01005572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737547326714509,"score_gpt":0.3800379170966809,"score_spread":0.3526624438295359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}