{"id":"W7132881131","doi":"","title":"Hijacking Cancer Signaling: First-in-class JPRK-targeting Ligands for Fibrolamellar Hepatocellular Carcinoma","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Allosteric regulation; In silico; Fusion protein; Ligand (biochemistry); Kinase; Cancer; Hepatocellular carcinoma; Mutant; Mutation; Drug discovery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780248,0.0004741923,0.0005113873,0.0003590673,0.0002175733,0.0005982684,0.0003731741,0.0003891874,0.001610114],"category_scores_gemma":[0.0001662833,0.0002117024,0.0003254963,0.0002127944,0.0002625555,0.0003549319,0.0003639534,0.0009503564,0.0009310445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006104728,"about_ca_system_score_gemma":0.0003320764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006405034,"about_ca_topic_score_gemma":0.002318586,"domain_scores_codex":[0.999912,0.00001356981,0.000004984981,0.00001335283,0.00002073009,0.00003530997],"domain_scores_gemma":[0.9999359,0.000009066182,0.00001212259,0.00000768208,0.00001211067,0.00002307777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007977677,0.0009994627,0.001034655,0.0004144011,0.00007257539,0.001017903,0.0001901935,0.005162445,0.9259883,0.001428077,0.0019272,0.06096702],"study_design_scores_gemma":[0.0009332825,0.01274097,0.004724574,0.0001030356,0.0001743733,0.004061287,0.0001949131,0.007649232,0.9192053,0.000771078,0.04932773,0.0001141645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650113,0.01081158,0.008351396,0.001042122,0.0001325531,0.0005495584,0.0009521521,0.0005011912,0.01264827],"genre_scores_gemma":[0.9753313,0.008109569,0.005536007,0.000511497,0.00003079788,0.000154002,0.001282194,0.00005775323,0.008986855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001610114,"threshold_uncertainty_score":0.005386293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02016399544394235,"score_gpt":0.3348611347303812,"score_spread":0.3146971392864388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}