{"id":"W7132885204","doi":"","title":"Identification and Characterization of Small Molecule Inhibitors of Polynucleotide Kinase 3'-Phosphatase","year":2012,"lang":"en","type":"dissertation","venue":"TSpace","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta","keywords":"DNA; Small molecule; DNA damage; Topoisomerase; DNA repair; Kinase; Camptothecin; DNA polymerase; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651947,0.0004971919,0.0003136816,0.0003565122,0.0001347285,0.0004066049,0.0002879611,0.0002366475,0.002041094],"category_scores_gemma":[0.0001600836,0.0001824395,0.0002981264,0.0002026028,0.0001283022,0.0002159107,0.0001440132,0.0005230037,0.0007192687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239872,"about_ca_system_score_gemma":0.0003615909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007640641,"about_ca_topic_score_gemma":0.001440701,"domain_scores_codex":[0.9999233,0.000007540747,0.000005792625,0.0000153887,0.00002852375,0.00001939961],"domain_scores_gemma":[0.9999313,0.00001192623,0.0000143524,0.000005364947,0.00001857323,0.0000184613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004908644,0.0005218951,0.0004499309,0.0001888188,0.00003710249,0.0001604887,0.00002391426,0.001140176,0.96042,0.0005926575,0.0006839693,0.03529016],"study_design_scores_gemma":[0.0003878534,0.002989059,0.00197606,0.00001867963,0.00007982318,0.0004797903,0.0000143438,0.002684952,0.9690827,0.0001226027,0.02214972,0.00001449563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9179165,0.03155925,0.0243619,0.0007437303,0.0002140304,0.001051923,0.002236736,0.0003733691,0.02154256],"genre_scores_gemma":[0.9407766,0.0181005,0.01601021,0.0003084237,0.00007446264,0.0005185365,0.005337948,0.0000716463,0.01880161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041094,"threshold_uncertainty_score":0.006828189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146004974790324,"score_gpt":0.2967543105713659,"score_spread":0.2821538130923334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}