{"id":"W7132901728","doi":"","title":"Using spatial transcriptomics to identify pathways for malignant transformation in pleomorphic adenoma","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"Salivary Gland Tumors Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Dentistry, University of Toronto; Canadian Institutes of Health Research; University of Toronto","keywords":"Transcriptome; Malignant transformation; Pleomorphic adenoma; Adenoma; Salivary gland; Carcinoma ex pleomorphic adenoma; Gene expression profiling; Gene expression; Immunofluorescence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485516,0.0002257155,0.0001327827,0.0005256339,0.0002065542,0.0004612039,0.000117379,0.0001915266,0.001516717],"category_scores_gemma":[0.0001467666,0.00008782811,0.000276484,0.0004468049,0.0002125245,0.0002291577,0.0002393154,0.0002838918,0.0004138436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883916,"about_ca_system_score_gemma":0.0003605098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000622552,"about_ca_topic_score_gemma":0.001463881,"domain_scores_codex":[0.999907,0.000007949749,0.000004243025,0.00002925315,0.00003535873,0.00001610955],"domain_scores_gemma":[0.9999281,0.00001789919,0.00002034726,0.000006425097,0.00001952672,0.000007671186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002632,0.00001697487,0.00544177,0.0001342858,0.00001393501,0.0000726721,0.00004726677,0.0002368178,0.9844189,0.0002210696,0.0001275614,0.00916847],"study_design_scores_gemma":[0.00002413478,0.0004517145,0.2347658,0.00007148164,0.0001322234,0.001260023,0.0006198465,0.005903603,0.7386095,0.001272885,0.01686435,0.00002448498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626328,0.005250495,0.02277168,0.0003702953,0.00003922502,0.0001113079,0.00379871,0.0002158364,0.004809582],"genre_scores_gemma":[0.9552764,0.005620435,0.02876986,0.0002340337,0.00003543017,0.0002086354,0.005477224,0.00004632472,0.004331738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516717,"threshold_uncertainty_score":0.005073965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09568165803234506,"score_gpt":0.402139084467726,"score_spread":0.3064574264353809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}