{"id":"W7132905998","doi":"","title":"Development of Class II-agnostic CAR T Cell Therapy Targeting WT1 Peptide Presented by Diverse HLA class II Molecules","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"T-cell receptor; Epitope; Chimeric antigen receptor; Human leukocyte antigen; T cell; Antigen; MHC class II; MHC class I; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046231,0.0004260783,0.0002796191,0.0002646372,0.000094123,0.000250677,0.0002836288,0.0003299447,0.0007966327],"category_scores_gemma":[0.000070527,0.0001592099,0.000237489,0.0001667426,0.0001187708,0.0002355968,0.0002055546,0.0005546216,0.0003496349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221466,"about_ca_system_score_gemma":0.0002063699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003616578,"about_ca_topic_score_gemma":0.0003196604,"domain_scores_codex":[0.9999008,0.00001063786,0.000005986624,0.00002753414,0.0000238856,0.00003121759],"domain_scores_gemma":[0.999975,0.000002149318,0.000006101724,0.000002802557,0.000005344117,0.000008614827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007234199,0.0001047914,0.0001280329,0.00006384036,0.000008263184,0.00008739109,0.00002557742,0.0005832044,0.9876736,0.0004438154,0.0001871492,0.01062206],"study_design_scores_gemma":[0.00009001501,0.00179047,0.0009685531,0.000009976375,0.00004518506,0.0008125388,0.0000171913,0.005581391,0.9758095,0.0001174913,0.01474367,0.00001400818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511201,0.004980721,0.03654579,0.0002824094,0.0001156711,0.0003779891,0.0003408177,0.0003785002,0.005858099],"genre_scores_gemma":[0.9805886,0.002760585,0.01154587,0.0001494138,0.00002301041,0.0002544261,0.0004337304,0.00002762887,0.004216765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007966327,"threshold_uncertainty_score":0.002665043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02581920271848318,"score_gpt":0.3408475716731513,"score_spread":0.3150283689546681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}