{"id":"W7132914567","doi":"","title":"Role of the mTOR Pathway and Autophagy in Mediating PARP Inhibitor Sensitivity in Small Cell Lung Cancer","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Autophagy; Sensitization; PI3K/AKT/mTOR pathway; mTORC1; PARP inhibitor; Lung cancer; Synthetic lethality; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001296064,0.0001498607,0.0001751953,0.0002276269,0.0002830621,0.0003393747,0.0001103764,0.0002216912,0.001949386],"category_scores_gemma":[0.0001046889,0.0000998522,0.0001952215,0.0001525597,0.0001492324,0.0001658714,0.0001560096,0.0003590358,0.0003525572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131537,"about_ca_system_score_gemma":0.0004062107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005185066,"about_ca_topic_score_gemma":0.001049871,"domain_scores_codex":[0.999946,0.000008865702,0.00000436092,0.00001002694,0.00001546114,0.00001525607],"domain_scores_gemma":[0.9999623,0.000008951774,0.00000833481,0.000003234561,0.000006139288,0.00001099878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003386537,0.0000981475,0.0009738741,0.0001852883,0.00001130483,0.0001326272,0.00003628691,0.0001703621,0.9833883,0.0006694907,0.0004087613,0.01358693],"study_design_scores_gemma":[0.00005879749,0.0008586539,0.03633018,0.00003761496,0.00004274236,0.0005272465,0.0001104998,0.00093377,0.9514187,0.0004179384,0.00925159,0.00001231575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967861,0.01610565,0.001574589,0.0007736845,0.00005450248,0.00009218445,0.0007184058,0.0001102988,0.01270973],"genre_scores_gemma":[0.9854662,0.00714779,0.00127732,0.0001531546,0.00001327153,0.00005273894,0.0004348159,0.00001453992,0.005440089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949386,"threshold_uncertainty_score":0.006521404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248906973587015,"score_gpt":0.3439584161153207,"score_spread":0.3314693463794506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}