{"id":"W7132919190","doi":"","title":"Structural and kinetic characterization of the Arabidopsis DHQ-SDH: The SDH catalytic mechanism and insights into the modes of substrate channeling and metabolism in the shikimate pathway","year":2007,"lang":"","type":"dissertation","venue":"TSpace","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Argonne National Laboratory; Natural Sciences and Engineering Research Council of Canada; Biological and Environmental Research; National Institutes of Health; University of Toronto; U.S. Department of Energy","keywords":"Shikimate pathway; Aromatic amino acids; Shikimic acid; Biosynthesis; Arabidopsis; Enzyme; Metabolic pathway; Mutant; Active site","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001208804,0.0004925567,0.0005739604,0.0001678822,0.0006266196,0.0002318711,0.0005259099,0.0002955824,0.00001920476],"category_scores_gemma":[0.0001285216,0.0002214379,0.00008167425,0.0005730973,0.0005582387,0.0002973276,0.0001303311,0.0004478476,5.317493e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002148571,"about_ca_system_score_gemma":0.00008486131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288257,"about_ca_topic_score_gemma":0.001699658,"domain_scores_codex":[0.9972882,0.0004889658,0.0007392053,0.0005613446,0.0005707013,0.0003516166],"domain_scores_gemma":[0.9978,0.0003078797,0.0009951729,0.000636232,0.0002081863,0.00005251903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000137196,0.000009346684,0.00006371331,0.000317386,0.00003164154,0.000001162402,0.1765406,0.000103133,0.8096127,0.0123047,3.627039e-7,0.0008780405],"study_design_scores_gemma":[0.0006465892,0.0001006072,0.1397805,0.0003865885,0.0004759563,0.00003707364,0.05823547,0.008951262,0.7755136,0.01545236,0.00001837878,0.0004015974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946299,0.002840219,0.0001229669,0.0003680642,0.0008192293,0.001088632,0.00002451355,0.000009639245,0.0000968553],"genre_scores_gemma":[0.9980382,0.001463195,0.00004398832,0.0001042761,0.0001323406,0.00003208346,0.0000707578,0.00003210886,0.00008306847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1397168,"threshold_uncertainty_score":0.9029975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373738819038394,"score_gpt":0.2634098291355027,"score_spread":0.2496724409451188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}