{"id":"W7132943989","doi":"","title":"Modelling the Effects of β-arrestin-Mediated Signaling in Cortical D2R Expressing Neurons using CRISPR-Cas9","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Dopamine; Signal transduction; Affect (linguistics); Schizophrenia (object-oriented programming); Dopamine receptor D2; Functional selectivity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008324783,0.0002512457,0.0002180262,0.0001193545,0.0001639225,0.0004399142,0.0004275546,0.0003622128,0.001709674],"category_scores_gemma":[0.0001184621,0.0001508186,0.0004324387,0.0001092739,0.0001872744,0.0001733731,0.0002269771,0.000484667,0.0003324182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006797995,"about_ca_system_score_gemma":0.0005247839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007355976,"about_ca_topic_score_gemma":0.007183388,"domain_scores_codex":[0.9999551,0.000003929907,0.000002337769,0.00001217099,0.00001693899,0.000009542778],"domain_scores_gemma":[0.9999604,0.00001431004,0.000009471004,0.000004133056,0.000005727022,0.000005939172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025505,0.000062548,0.0009924934,0.000202922,0.00003627593,0.0002719364,0.000046701,0.1070415,0.8811713,0.004150373,0.0003826531,0.00553877],"study_design_scores_gemma":[0.00004948941,0.0002657062,0.00401079,0.00002668244,0.00006712681,0.000229788,0.00009117595,0.5128517,0.4728947,0.002257935,0.00721224,0.0000427144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8790847,0.0007800199,0.09742378,0.0003387767,0.00008403768,0.00009995104,0.001666766,0.0005973731,0.01992455],"genre_scores_gemma":[0.9695252,0.0009153608,0.02146308,0.00005417505,0.000003833134,0.00007560323,0.0004141809,0.00007711922,0.007471574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007355976,"threshold_uncertainty_score":0.01462632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02802549391152688,"score_gpt":0.3202894425384232,"score_spread":0.2922639486268964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}