{"id":"W7132951356","doi":"","title":"Plasma Neurofilament Light Chain as a Biomarker of Global Cognition in the Early Stages of Cognitive Impairment","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cognition; Neurocognitive; Biomarker; Montreal Cognitive Assessment; Plasma levels; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003072778,0.0002904227,0.0002279422,0.0004755251,0.0001906073,0.0004400224,0.0001310833,0.0002813232,0.001198945],"category_scores_gemma":[0.000619624,0.00008673463,0.0001550795,0.0003139461,0.000157615,0.0001923217,0.0002326571,0.0003941283,0.0001535401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625155,"about_ca_system_score_gemma":0.0002167138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004732507,"about_ca_topic_score_gemma":0.007122768,"domain_scores_codex":[0.9999481,0.00001053483,0.000004295085,0.00001223244,0.00001293392,0.00001174284],"domain_scores_gemma":[0.9997492,0.00003569437,0.00007823881,0.00001128966,0.00004815338,0.00007749739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001588292,0.0002553159,0.9729899,0.00005408835,0.00010747,0.0001357747,0.000213019,0.0001147786,0.006774392,0.00003391742,0.0002669191,0.01746618],"study_design_scores_gemma":[0.000008315973,0.0002214937,0.9989792,0.000007743042,0.00002249958,0.00006927154,0.00008235507,0.00006965955,0.000412867,0.00003202618,0.00009241257,0.000002049266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987208,0.0006341493,0.00006648828,0.00005032133,0.000006697076,0.000007725625,0.00008442238,0.000002945588,0.0004262833],"genre_scores_gemma":[0.9985875,0.0003010384,0.0001720048,0.00003010227,0.000008886529,0.000006539306,0.0001177145,7.565524e-7,0.0007754536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004732507,"threshold_uncertainty_score":0.009409964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850158980601342,"score_gpt":0.3453012868326178,"score_spread":0.3267996970266044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}