{"id":"W7132957676","doi":"","title":"Validating SCAP as a Therapeutic Target for Colorectal Cancer","year":2024,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Gene knockdown; Transcription factor; Colorectal cancer; Cell growth; Lipid metabolism; Cell culture; Sterol regulatory element-binding protein; Autophagy; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007216258,0.0003787303,0.0005982493,0.0004832757,0.0003005599,0.0008722428,0.0003778426,0.0005802407,0.002605249],"category_scores_gemma":[0.0004806112,0.0001843177,0.0005897622,0.0003495672,0.0003233083,0.0003466638,0.0004742467,0.001258243,0.001545546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005470408,"about_ca_system_score_gemma":0.0008242464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003634423,"about_ca_topic_score_gemma":0.0008749953,"domain_scores_codex":[0.9996625,0.00008550712,0.00002704606,0.00005318876,0.0001146995,0.00005712169],"domain_scores_gemma":[0.9998136,0.0000340863,0.00002372461,0.00002720916,0.00006468975,0.00003671638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001188217,0.0002843715,0.001874835,0.001338868,0.0001501101,0.0003413844,0.00007733201,0.000975278,0.9397616,0.00129537,0.003863141,0.04884955],"study_design_scores_gemma":[0.0004537826,0.004369655,0.009219832,0.0003505307,0.0004581712,0.002284013,0.0002635676,0.003160897,0.7963949,0.001115923,0.1818785,0.00005031433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8367122,0.1067685,0.01695124,0.007254898,0.001225552,0.0009384776,0.009073875,0.0007653526,0.02030991],"genre_scores_gemma":[0.9187878,0.04526,0.01409108,0.002094121,0.0002168432,0.000608555,0.01086947,0.0001223165,0.00794976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002605249,"threshold_uncertainty_score":0.008715451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542964613976922,"score_gpt":0.3572864484610004,"score_spread":0.3418568023212312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}