{"id":"W7132957709","doi":"","title":"Investigating the Mechanisms and Kinetics of Circulating Tumour DNA Release to Improve its Clinical Utility","year":2021,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Head and neck squamous-cell carcinoma; Circulating tumor DNA; Cancer; Malignancy; Disease; Radiation therapy; Clinical trial; Kinetics; Personalized medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001209696,0.000376094,0.0006740825,0.0006182406,0.0002634173,0.00108649,0.0003498874,0.0006654229,0.001655091],"category_scores_gemma":[0.002322567,0.0003629536,0.0005364428,0.0004576569,0.0003970492,0.0008479761,0.0003828612,0.001321472,0.0007246293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008151947,"about_ca_system_score_gemma":0.0007304599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009927384,"about_ca_topic_score_gemma":0.001115825,"domain_scores_codex":[0.9994122,0.0001258039,0.00004471454,0.0001674535,0.0001783438,0.00007157121],"domain_scores_gemma":[0.9989311,0.000338676,0.0003067744,0.00008749167,0.0002574387,0.00007848299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002683522,0.0003939111,0.08894919,0.002530851,0.0002347845,0.0005157207,0.0007645952,0.003374514,0.6884614,0.001473967,0.003712824,0.2069047],"study_design_scores_gemma":[0.0001819692,0.007059101,0.1584298,0.0005725268,0.0006888977,0.002919448,0.001218917,0.02104489,0.750931,0.003073701,0.05371227,0.0001673572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8071159,0.1363587,0.04282519,0.003058199,0.0007431143,0.0005309043,0.001552316,0.0005452444,0.007270547],"genre_scores_gemma":[0.9611505,0.0211583,0.01167913,0.001037261,0.0002399483,0.0002648191,0.0007235164,0.00008448005,0.003662172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655091,"threshold_uncertainty_score":0.006397545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725251899272857,"score_gpt":0.3411005178207289,"score_spread":0.3138479988280004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}