{"id":"W7132962232","doi":"","title":"Identifying Mitochondrial Stress Response Factors using CRISPR/Cas9 GenomicScreening","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mitochondrial DNA; Mitochondrion; DNA repair; Nuclear DNA; mitochondrial fusion; DNA damage; Nuclear gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002787266,0.0006080896,0.0004321813,0.0004290054,0.0002645186,0.0006325904,0.0004834786,0.0005329855,0.002253547],"category_scores_gemma":[0.0002801044,0.0002729571,0.0004673928,0.0002441006,0.000325542,0.0002871222,0.0004433803,0.001091638,0.000948779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972633,"about_ca_system_score_gemma":0.0003604971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000844014,"about_ca_topic_score_gemma":0.002041151,"domain_scores_codex":[0.999613,0.00002635037,0.00005109634,0.0001268429,0.0001281755,0.00005456732],"domain_scores_gemma":[0.9997872,0.00004622207,0.00007195545,0.00002757941,0.00002378197,0.00004320587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003475741,0.00001953064,0.0001188644,0.000053099,0.000006106317,0.00005613054,0.00001371378,0.0001514805,0.996814,0.0001481598,0.0001117957,0.002472519],"study_design_scores_gemma":[0.00001351169,0.0001231664,0.001372678,0.00001112842,0.00002259972,0.000316139,0.00002621703,0.002586433,0.9869609,0.0001083063,0.008440739,0.0000181669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8358771,0.003029707,0.1405504,0.0007519049,0.000278576,0.0006568893,0.006990951,0.003407637,0.008456707],"genre_scores_gemma":[0.8702494,0.002358517,0.1070132,0.0004173497,0.00003002331,0.0003127158,0.006515877,0.0005715586,0.01253141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002253547,"threshold_uncertainty_score":0.007538795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06283638869645618,"score_gpt":0.3744603736287642,"score_spread":0.311623984932308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}