{"id":"W7132971336","doi":"","title":"The Alzheimer's Spectrum: Diagnostic Challenges and Nosology in a Clinically Heterogeneous Disease","year":2017,"lang":"","type":"dissertation","venue":"TSpace","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nosology; Conceptualization; Disease; Clinical phenotype; Medical diagnosis; Classification scheme; Multimorbidity; Clinical Practice","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01738299,0.0004050898,0.001435185,0.006923927,0.0006297199,0.003166679,0.0009968232,0.0009822976,0.001306595],"category_scores_gemma":[0.03273102,0.000236891,0.0009922486,0.005663793,0.003275171,0.00533603,0.001678973,0.001250579,0.0002856568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002564887,"about_ca_system_score_gemma":0.008737385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003416521,"about_ca_topic_score_gemma":0.006697579,"domain_scores_codex":[0.9937117,0.002942751,0.001458368,0.0005150135,0.00124823,0.0001239989],"domain_scores_gemma":[0.9790031,0.01454548,0.003684021,0.0005153286,0.001953127,0.0002989462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004691847,0.00006211518,0.04478249,0.08817938,0.002182978,0.002079805,0.005795822,0.0008146861,0.001478041,0.04920096,0.01676181,0.7881927],"study_design_scores_gemma":[0.0004335287,0.0008973727,0.1137335,0.270481,0.009632922,0.01574784,0.0303589,0.002195814,0.001934324,0.2424576,0.3118604,0.0002666728],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01486431,0.9426051,0.003962527,0.03277932,0.0005874551,0.0001851986,0.0003006901,0.0000190711,0.004696291],"genre_scores_gemma":[0.2930647,0.6671101,0.0209284,0.01530342,0.001665032,0.0004224476,0.0007199129,0.00001564657,0.0007703286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01738299,"threshold_uncertainty_score":0.09193116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0831142552646644,"score_gpt":0.4530855486375506,"score_spread":0.3699712933728861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}