{"id":"W7132978915","doi":"","title":"Enzyme microencapsulation and its application for overcoming multidrug resistance in breast cancer treatment","year":2008,"lang":"","type":"dissertation","venue":"TSpace","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Cytotoxicity; Multiple drug resistance; Doxorubicin; Intracellular; Reactive oxygen species; Cancer cell; Extracellular; Glucose oxidase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001530509,0.0002154499,0.0001685534,0.0001865565,0.00008997631,0.0002497118,0.0001163294,0.0002469455,0.0004163542],"category_scores_gemma":[0.00009890296,0.0001071544,0.0002939028,0.0001580555,0.000143969,0.00019133,0.0001533172,0.0003344491,0.0001218554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576863,"about_ca_system_score_gemma":0.0001905012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004747389,"about_ca_topic_score_gemma":0.0006478787,"domain_scores_codex":[0.9999093,0.00001182072,0.000006297702,0.0000257061,0.00003498125,0.00001195438],"domain_scores_gemma":[0.9999627,0.000007924221,0.00001341117,0.000003901381,0.000007305086,0.000004704411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002614243,0.00001650489,0.00009587001,0.0001399731,0.000007548538,0.00005726484,0.00001753115,0.0002198225,0.9883171,0.0002638749,0.00006270118,0.01077563],"study_design_scores_gemma":[0.000004630092,0.0001969116,0.0006652882,0.000009730059,0.00001795574,0.0001568502,0.000008692432,0.0008584828,0.9913859,0.00004211377,0.006648189,0.000005203066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8757446,0.0618808,0.05534979,0.0006554443,0.0002389249,0.0001328783,0.0001915434,0.0002430131,0.005562885],"genre_scores_gemma":[0.9546657,0.02079393,0.0196373,0.00008890758,0.00003663859,0.00006130029,0.0001062053,0.00002165901,0.004588429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004747389,"threshold_uncertainty_score":0.001869678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773453824881279,"score_gpt":0.309884179509943,"score_spread":0.2921496412611302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}