{"id":"W7132981103","doi":"","title":"Clinical, Molecular, and Management Perspectives on Replication Repair Deficiency Syndromes","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Stand Up To Cancer; Fondation Brain Canada; Hospital for Sick Children; Ministerstvo Zdravotnictví Ceské Republiky; Garron Family Cancer Centre; Bristol-Myers Squibb; V Foundation for Cancer Research","keywords":"DNA mismatch repair; Cancer; Genetic testing; Genome; Pathognomonic; Genomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00117493,0.0006153437,0.0005577389,0.001161316,0.0004342486,0.001624136,0.0006818203,0.001231507,0.005032132],"category_scores_gemma":[0.002041815,0.0001905973,0.0005003819,0.0007990946,0.0008771327,0.001276294,0.001156004,0.002973234,0.001532957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001043885,"about_ca_system_score_gemma":0.001723332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178256,"about_ca_topic_score_gemma":0.001875109,"domain_scores_codex":[0.9995266,0.000141124,0.00004841578,0.00008715431,0.0001346522,0.00006215251],"domain_scores_gemma":[0.9991748,0.0003773389,0.00008869029,0.000029962,0.0002178584,0.0001112565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001565991,0.0001178375,0.00384827,0.002930877,0.00006508565,0.001429446,0.0008397905,0.0006477916,0.004378525,0.03372974,0.1909246,0.7609314],"study_design_scores_gemma":[0.00002558332,0.0001850477,0.004588088,0.004998819,0.00007322747,0.007896894,0.0005953556,0.0001877957,0.001052832,0.01862861,0.9617259,0.00004189057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.004647044,0.8984414,0.004464448,0.06013908,0.005299274,0.00005314383,0.0003718855,0.0001504,0.02643333],"genre_scores_gemma":[0.02825783,0.9239521,0.009180023,0.01532508,0.01178,0.0001368348,0.0006215209,0.00007746353,0.01066927],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005032132,"threshold_uncertainty_score":0.01683414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699048075893361,"score_gpt":0.4137535271637381,"score_spread":0.3767630464048045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}