{"id":"W7132983557","doi":"","title":"Investigating a Potential Hotspot for the Interaction of a Group of Corrector Compounds on F508del-CFTR","year":2024,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Mutant; Regulator; Transmembrane protein; Negative regulator; Potentiator; Binding site; Protein folding","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500688,0.0002000135,0.0002424861,0.0001591014,0.000286457,0.0003165238,0.0002093696,0.0003997611,0.007406848],"category_scores_gemma":[0.0001354075,0.0001170835,0.0002501915,0.0001277118,0.0001487394,0.000257076,0.0002388804,0.0003578961,0.0009220281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002484027,"about_ca_system_score_gemma":0.0002504397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003745663,"about_ca_topic_score_gemma":0.0006164673,"domain_scores_codex":[0.9999157,0.0000103152,0.000002817669,0.00001986951,0.00002937543,0.00002192655],"domain_scores_gemma":[0.999957,0.00001115621,0.00001059503,0.00000271426,0.000007679335,0.00001096326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002408579,0.00007780332,0.0006034353,0.0001355905,0.00001075585,0.0002068449,0.00007088574,0.0002472825,0.9853289,0.0007525564,0.0003932338,0.0119318],"study_design_scores_gemma":[0.00005912706,0.001490009,0.006660762,0.00002925707,0.00003684443,0.0005919451,0.0002041671,0.0008450483,0.9724506,0.000426318,0.01719503,0.00001088211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682376,0.007255287,0.004894698,0.000798722,0.00008719145,0.0001163417,0.0003687297,0.000131233,0.01811032],"genre_scores_gemma":[0.9622691,0.005482611,0.006304578,0.0004346412,0.00003195291,0.00005780503,0.000491146,0.00003587461,0.02489229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007406848,"threshold_uncertainty_score":0.02477843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660294054900359,"score_gpt":0.4040129546202851,"score_spread":0.3674100140712815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}