{"id":"W7132989046","doi":"","title":"Studying the Regulation and Function of Biomolecular Condensates with In vitro Reconstitution","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Function (biology); Protein–protein interaction; Intrinsically disordered proteins; Phosphorylation; Protein domain; Protein structure; In vitro; Protein aggregation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008257173,0.0008128998,0.0006147534,0.0004477657,0.0004245816,0.001010593,0.001081252,0.0008250968,0.000934837],"category_scores_gemma":[0.0007829824,0.0005867414,0.0008420496,0.0004046117,0.0009846691,0.0008749645,0.0009720817,0.0023856,0.00080536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001250623,"about_ca_system_score_gemma":0.0003510152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001349993,"about_ca_topic_score_gemma":0.001081212,"domain_scores_codex":[0.9994743,0.00008538575,0.00006906168,0.000153555,0.0001434456,0.00007422547],"domain_scores_gemma":[0.9996411,0.000133892,0.00009719864,0.0000604952,0.00002745232,0.00003987438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004496517,0.00005243823,0.0002886734,0.0001896795,0.00001770508,0.00005918232,0.00008893575,0.0008810192,0.9927219,0.002407181,0.0002076979,0.00304055],"study_design_scores_gemma":[0.00001296384,0.0001106221,0.0008391963,0.0000268788,0.00001881236,0.0001164878,0.00003742044,0.00406884,0.9841145,0.0005528988,0.01007903,0.00002235798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7251015,0.03162636,0.2225106,0.00254596,0.001079367,0.0006689959,0.00328614,0.002493578,0.01068743],"genre_scores_gemma":[0.9076887,0.01835955,0.06497838,0.0004277321,0.0001465078,0.0005852411,0.001902299,0.0003107593,0.005600756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001349993,"threshold_uncertainty_score":0.009073973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171139700890206,"score_gpt":0.2622019538367852,"score_spread":0.2504905568278832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}