{"id":"W7132991242","doi":"","title":"Uncovering Novel Anthelmintics: Targeting Caenorhabditis elegans Hyperosmotic Stress Recovery with Small Molecules","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Caenorhabditis elegans; Osmotic concentration; Anthelmintic; Population; Osmotic shock; Small molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753791,0.0005028491,0.0003612398,0.0003987426,0.0002333467,0.0004712986,0.000240091,0.0003819105,0.002185226],"category_scores_gemma":[0.0001219757,0.0002136474,0.0004521542,0.0002302444,0.0001564393,0.0003789867,0.0002326695,0.000957372,0.0007593745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000434288,"about_ca_system_score_gemma":0.000357709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005755984,"about_ca_topic_score_gemma":0.002128089,"domain_scores_codex":[0.999941,0.000005002008,0.00000356605,0.00001367685,0.00002244482,0.00001432108],"domain_scores_gemma":[0.9999454,0.000006734587,0.00001145059,0.000002744959,0.00001437264,0.0000192748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704279,0.0001061888,0.0002763656,0.0005108361,0.00003954804,0.0001022464,0.00003879414,0.0003372205,0.9610236,0.000640924,0.002060128,0.03469378],"study_design_scores_gemma":[0.0002193155,0.001794345,0.005127997,0.0001639528,0.000201223,0.0002958379,0.00006186001,0.00136897,0.9084713,0.0004955987,0.08176175,0.00003783551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8071681,0.1080938,0.03403993,0.0072392,0.001040349,0.00108145,0.003766632,0.001552182,0.03601826],"genre_scores_gemma":[0.770264,0.1173984,0.0405761,0.003366537,0.0002114227,0.0006203707,0.0042614,0.0001815129,0.06312019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002185226,"threshold_uncertainty_score":0.007310331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143780831277797,"score_gpt":0.245266007147794,"score_spread":0.233828198835016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}