{"id":"W7132993539","doi":"","title":"Broadly conserved surface molecules mediate cellular entry of engineered bacterial toxins","year":2024,"lang":"","type":"dissertation","venue":"TSpace","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Bespoke; Effector; Function (biology); Receptor; Cytosol; Microbial toxins; Linker; Lipid-anchored protein; In vivo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009497845,0.0003082199,0.0001170012,0.00009135302,0.00007907512,0.0003674797,0.0001464106,0.0001796987,0.001244604],"category_scores_gemma":[0.00006008396,0.00009425539,0.0001328168,0.00007959092,0.0001770263,0.0001758168,0.0003039406,0.0003684658,0.0005988525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731229,"about_ca_system_score_gemma":0.0001691657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002200818,"about_ca_topic_score_gemma":0.0003730168,"domain_scores_codex":[0.9999304,0.000006433831,0.000002706274,0.00001074115,0.00002424738,0.00002549842],"domain_scores_gemma":[0.9999796,0.000003846419,0.000005002095,0.000002717412,0.00000347432,0.000005316007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001136945,0.0000123625,0.00005026065,0.00002230784,0.000001357248,0.0000268933,0.00001900813,0.0000964417,0.9967007,0.0009398428,0.00006501166,0.002054497],"study_design_scores_gemma":[0.000005562415,0.0001034465,0.0005196739,0.000005560532,0.00000378935,0.00006940257,0.00002442645,0.0003799074,0.9944751,0.0001334927,0.004278122,0.000001632604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675455,0.002160707,0.0188287,0.0001890103,0.00003791767,0.00007248528,0.0001897436,0.0001104497,0.0108654],"genre_scores_gemma":[0.9757035,0.002568235,0.006439387,0.00008350729,0.00000680069,0.00004042549,0.0002517943,0.00002025754,0.01488623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244604,"threshold_uncertainty_score":0.004163623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009443197658808172,"score_gpt":0.2526776082594296,"score_spread":0.2432344106006215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}