{"id":"W7132994236","doi":"","title":"Identifying Sources of Missing Heritability and Translating Genomic Variation in Nicotine Metabolism","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Missing heritability problem; Heritability; Genetic variation; CYP2A6; Nicotine; Genotyping; Genetic association; Allele; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008326674,0.001234338,0.001091607,0.001852876,0.0006479631,0.00196966,0.0008405649,0.0007940975,0.002195341],"category_scores_gemma":[0.02886877,0.0005812559,0.001511845,0.002357205,0.001002936,0.0009988653,0.001567627,0.001236946,0.0002586695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005051962,"about_ca_system_score_gemma":0.0008815927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009566377,"about_ca_topic_score_gemma":0.008659261,"domain_scores_codex":[0.9945434,0.002957805,0.0003366511,0.001281911,0.0006034813,0.0002766926],"domain_scores_gemma":[0.9864435,0.01040335,0.0009419977,0.001640182,0.0004166566,0.0001543314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006255558,0.0001919549,0.7863537,0.0004719287,0.005165021,0.002221143,0.003695936,0.01463012,0.01417987,0.01912525,0.001465365,0.1518743],"study_design_scores_gemma":[0.00009471791,0.0004680515,0.8594419,0.0005398329,0.003819872,0.001678005,0.00153312,0.06399836,0.006855061,0.05255519,0.008837062,0.000178852],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.875378,0.001965936,0.1159331,0.001095098,0.0001526789,0.0001029986,0.00201499,0.0002860116,0.003071289],"genre_scores_gemma":[0.9643219,0.0007973154,0.03304287,0.000219744,0.00005641514,0.0001006278,0.0007575301,0.0001168116,0.0005867038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009566377,"threshold_uncertainty_score":0.04403621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955163364526069,"score_gpt":0.3257429087063435,"score_spread":0.3061912750610828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}