{"id":"W7133016253","doi":"","title":"Functional Characterization of Proximity-dependent Degraders","year":2020,"lang":"","type":"dissertation","venue":"TSpace","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Degron; Ubiquitin; Proteasome; Ubiquitin-Protein Ligases; Protein degradation; Ubiquitin ligase; Identification (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004692522,0.0003349048,0.0003068811,0.0004455436,0.0001714054,0.0004127883,0.000253373,0.0002727924,0.001618148],"category_scores_gemma":[0.0005331349,0.0001171867,0.0003927885,0.0003139767,0.000128161,0.0003072424,0.0002214512,0.0003322899,0.0009280089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716893,"about_ca_system_score_gemma":0.0001582418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006758893,"about_ca_topic_score_gemma":0.0004219245,"domain_scores_codex":[0.9995851,0.00004513524,0.00005338649,0.0001033394,0.0001544046,0.00005858988],"domain_scores_gemma":[0.9996588,0.00006662185,0.0000599062,0.0000418107,0.000117079,0.00005573078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005640794,0.00002004688,0.000402113,0.00002826861,0.00000545326,0.00005395161,0.00001071319,0.00009262478,0.9976113,0.00005618534,0.00003257146,0.001630377],"study_design_scores_gemma":[0.000003850434,0.0001462775,0.003527414,0.000003291573,0.000009805918,0.0003625634,0.00001838954,0.0006057036,0.9931966,0.00002632672,0.002095789,0.000003944317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752373,0.004047044,0.01425562,0.0001437491,0.00002885796,0.00008880465,0.002064561,0.0001307585,0.004003331],"genre_scores_gemma":[0.9752754,0.001563579,0.01043179,0.00009832019,0.00001280437,0.00005175751,0.005072155,0.00009307649,0.007401072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618148,"threshold_uncertainty_score":0.005413234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01918371555198283,"score_gpt":0.2752218438707802,"score_spread":0.2560381283187974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}