{"id":"W7133023578","doi":"","title":"Functional Properties of Monomers and Oligomers ofthe M2 Muscarinic Receptor","year":2014,"lang":"","type":"dissertation","venue":"TSpace","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Allosteric regulation; Cooperativity; G protein-coupled receptor; Receptor; Cooperative binding; Binding site; Monomer; G protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002295525,0.0002054393,0.000132563,0.000177584,0.0001833776,0.0003680688,0.0001875952,0.0003347164,0.002223298],"category_scores_gemma":[0.000363674,0.0001311005,0.000159908,0.0001497543,0.0001965343,0.0003404767,0.000130806,0.0002899844,0.0006492891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403354,"about_ca_system_score_gemma":0.00008395631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004698213,"about_ca_topic_score_gemma":0.0003531287,"domain_scores_codex":[0.9998274,0.00002331116,0.00001140015,0.00004468379,0.00005452154,0.00003870945],"domain_scores_gemma":[0.9998664,0.00002878445,0.00002987431,0.00001579055,0.00002848428,0.00003064138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001716562,0.00002801363,0.0006638405,0.00004019956,0.000006856039,0.00002991318,0.00004072869,0.0001059238,0.9953628,0.0004029281,0.0001340685,0.003012944],"study_design_scores_gemma":[0.00002539988,0.0005452816,0.03810121,0.00002041966,0.00003274936,0.0004829223,0.0001589286,0.003344669,0.9511908,0.0005150657,0.005563158,0.00001934683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921842,0.002382485,0.001418291,0.0001021417,0.00002411083,0.00001211115,0.0003346272,0.00001706506,0.00352506],"genre_scores_gemma":[0.9949527,0.0008251062,0.0005254456,0.00007330249,0.00001940016,0.00001516708,0.0004588445,0.00001331129,0.003116674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002223298,"threshold_uncertainty_score":0.007437646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902110545346411,"score_gpt":0.2575938732074195,"score_spread":0.2385727677539554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}