{"id":"W7133024986","doi":"","title":"Chloride Dysregulation and Impaired Gamma-Amino Butyric Acid Signaling in the Basal Ganglia in Huntington's Disease","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"GABAergic; Cotransporter; Basal ganglia; GABAA receptor; Huntingtin; Inhibitory postsynaptic potential; Indirect pathway of movement; Neurotransmission","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147943,0.0004208788,0.0003352392,0.0004091166,0.0002421234,0.000521565,0.0002988723,0.0005580766,0.001599562],"category_scores_gemma":[0.0001486234,0.0001194328,0.0002876631,0.000207912,0.0005505067,0.0002878173,0.0005380936,0.0007628356,0.0003348626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004481855,"about_ca_system_score_gemma":0.0002568411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009954785,"about_ca_topic_score_gemma":0.0009922755,"domain_scores_codex":[0.9999532,0.000004508574,0.000005116208,0.00001216886,0.00001211747,0.00001290259],"domain_scores_gemma":[0.999941,0.00000615478,0.0000199358,0.000001639159,0.000009940833,0.00002137959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005486406,0.000817683,0.2478464,0.001862865,0.0004055243,0.07898112,0.006595766,0.00182575,0.4337176,0.009533999,0.02325201,0.189675],"study_design_scores_gemma":[0.000282572,0.00292188,0.8224337,0.0008810043,0.0005717221,0.04855835,0.003118535,0.002075573,0.06703857,0.01366999,0.03828694,0.0001611844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498436,0.03466857,0.001875992,0.006243535,0.0006493324,0.00005094775,0.0002295818,0.00007018751,0.006368078],"genre_scores_gemma":[0.9716097,0.0200187,0.0009603541,0.00120762,0.0004056326,0.00005044943,0.0002080925,0.00001250723,0.005526922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599562,"threshold_uncertainty_score":0.005351007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05205546190942515,"score_gpt":0.3473248904076593,"score_spread":0.2952694284982341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}