{"id":"W7133026931","doi":"","title":"Pharmacological Targeting of Helicases","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Helicase; RNA Helicase A; Drug discovery; Enzyme; DNA; ATP hydrolysis; Translation (biology); RNA; Chemical biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478365,0.0004383652,0.0003157525,0.000517937,0.0002720057,0.000554888,0.000216092,0.0002739582,0.002887109],"category_scores_gemma":[0.0001235693,0.0001173373,0.0003730991,0.0003354424,0.0001877475,0.0001981438,0.0002590777,0.000644346,0.0006596841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006306072,"about_ca_system_score_gemma":0.000401751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009215324,"about_ca_topic_score_gemma":0.003078907,"domain_scores_codex":[0.9999094,0.00001268686,0.000005803447,0.00002002811,0.00002173585,0.00003028662],"domain_scores_gemma":[0.9999608,0.000004908548,0.00000846128,0.000004345901,0.000009187156,0.00001226796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005149671,0.0004031042,0.0007376148,0.0007077139,0.00008333299,0.0002356857,0.00005835361,0.001761066,0.9044591,0.003670059,0.002431727,0.08493736],"study_design_scores_gemma":[0.0006935287,0.0059706,0.009748484,0.0002441285,0.0002155224,0.001687674,0.0001312911,0.004831732,0.8494242,0.002315818,0.1246889,0.00004822254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8127124,0.0742881,0.02431556,0.001990274,0.0003980788,0.001152157,0.004782047,0.0008495662,0.07951181],"genre_scores_gemma":[0.9363213,0.03579257,0.009569051,0.0005455076,0.00006546519,0.0002466816,0.002406515,0.00002961694,0.01502339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002887109,"threshold_uncertainty_score":0.009658337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751879384014712,"score_gpt":0.352220231962488,"score_spread":0.3347014381223409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}