{"id":"W7133031853","doi":"","title":"Developing AAV Gene Therapy Tools for Neurodevelopmental Epileptic Encephalopathies","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Dravet syndrome; Sodium channel; GABAergic; Genetic enhancement; Epilepsy; Disease; Gene; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004234831,0.0004078471,0.0003160682,0.0004852733,0.0001836526,0.0007868591,0.0004484706,0.0006946262,0.001613899],"category_scores_gemma":[0.0002481823,0.0002804536,0.0004127653,0.000163884,0.0004017956,0.0005494697,0.0004068662,0.001060602,0.0006419778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856924,"about_ca_system_score_gemma":0.0004239991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004097289,"about_ca_topic_score_gemma":0.0005181205,"domain_scores_codex":[0.9997471,0.00003706462,0.00001955224,0.00004396011,0.000109143,0.0000431812],"domain_scores_gemma":[0.9999043,0.00001934546,0.00003094576,0.000008358157,0.0000167913,0.00002024717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004383019,0.00008039755,0.0002266352,0.0002560312,0.00001805697,0.000226558,0.0001274521,0.000562755,0.9699628,0.005031514,0.000327089,0.02313694],"study_design_scores_gemma":[0.00007131168,0.001913054,0.001017826,0.0001909838,0.00009158007,0.001435638,0.0001264495,0.004673311,0.9235234,0.002029127,0.06489757,0.00002965001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5603952,0.02707988,0.3807596,0.001879827,0.0006806755,0.001374232,0.0008487236,0.002254302,0.02472764],"genre_scores_gemma":[0.7035452,0.02280199,0.2512909,0.0005164962,0.00009132969,0.0008869304,0.0008383646,0.0001832976,0.01984543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613899,"threshold_uncertainty_score":0.005398989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08840024541917284,"score_gpt":0.4023454631047377,"score_spread":0.3139452176855648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}