{"id":"W7133035039","doi":"","title":"SHH Pathway Activation in Dedifferentiation During Tumour Progression in MPNST","year":2024,"lang":"","type":"dissertation","venue":"TSpace","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"U.S. Department of Defense","keywords":"Neural crest; Carcinogenesis; Proto-oncogene tyrosine-protein kinase Src; Transcription factor; Cell growth; Nerve sheath neoplasm; Neurofibroma; Cell; Malignant peripheral nerve sheath tumor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007143386,0.00009202697,0.00006264565,0.0001853777,0.00009192005,0.0001220785,0.00005311665,0.0001200577,0.0009924774],"category_scores_gemma":[0.00005603888,0.00005140039,0.00007687777,0.00007836821,0.00008658961,0.00009280973,0.00009767384,0.0001364348,0.0002133718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581855,"about_ca_system_score_gemma":0.0001005767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003323726,"about_ca_topic_score_gemma":0.0006395476,"domain_scores_codex":[0.9999636,0.000007185818,0.000002275104,0.00000607381,0.000009091309,0.00001173682],"domain_scores_gemma":[0.9999844,0.000003196573,0.000003648404,9.664598e-7,0.000002052541,0.000005749794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005217315,0.00005642043,0.008544292,0.00008711375,0.00000719213,0.001055475,0.0001005173,0.0001287679,0.9765523,0.0002565536,0.0001477626,0.0125418],"study_design_scores_gemma":[0.0000611735,0.001288242,0.297644,0.00002961042,0.00004223716,0.005893072,0.0003990627,0.001499838,0.6809901,0.0004182081,0.01172544,0.000008934501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963422,0.001486697,0.0002130349,0.00003470818,0.000004502588,0.000009774228,0.00004527987,0.000009329045,0.001854426],"genre_scores_gemma":[0.9967805,0.001091147,0.000227757,0.00001292996,0.000004549216,0.00001103238,0.0001028046,0.000001808082,0.001767362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009924774,"threshold_uncertainty_score":0.003320158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970037094497986,"score_gpt":0.3366599881749045,"score_spread":0.3169596172299247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}