{"id":"W7133035917","doi":"","title":"Investigating the Roles of Truncated Kinases in Oncogenic Signal Rewiring","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Kinase; Biotinylation; Carcinogenesis; Signal transduction; Protein kinase A; Identification (biology); Protein–protein interaction; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000359703,0.000427487,0.0005115214,0.000135059,0.0002386234,0.00002624664,0.0004018694,0.0008471143,0.00002493928],"category_scores_gemma":[0.0003690624,0.0003296099,0.0002500001,0.0004925554,0.0002525155,0.00000241996,0.0001870562,0.0006518491,0.000003013613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000352012,"about_ca_system_score_gemma":0.0004945731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003324771,"about_ca_topic_score_gemma":0.001874532,"domain_scores_codex":[0.9979525,0.000240218,0.0006554234,0.0005568518,0.0002114973,0.000383475],"domain_scores_gemma":[0.998726,0.0001080096,0.0005128395,0.000388811,0.0002100966,0.00005424491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485806,0.0001176987,0.002039948,0.0006757965,0.0006277623,0.000004603221,0.009590164,0.0006635811,0.9763421,0.0001030612,0.0005287546,0.009157917],"study_design_scores_gemma":[0.0007862673,0.0002503068,0.003147838,0.001844957,0.0002885174,0.000003675794,0.03418197,0.0004302853,0.9563059,0.00007731617,0.002241582,0.0004413757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472529,0.04426046,0.00001493604,0.000579411,0.0003314546,0.0004040736,0.00001247339,0.000009495972,0.00713475],"genre_scores_gemma":[0.9843047,0.006472737,0.000109193,0.0000950429,0.0001097605,0.0000273336,0.0003632933,0.00002921873,0.008488755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03778772,"threshold_uncertainty_score":0.9999156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568981521675276,"score_gpt":0.3085541875101834,"score_spread":0.2928643722934307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}