{"id":"W7133038255","doi":"","title":"Validation of a Novel Optogenetic Drug Screening Platform for the Discovery of Neuroactive Compounds","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Optogenetics; Drug discovery; Glutamatergic; Zebrafish; GABAergic; Drug; Excitatory postsynaptic potential; Nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000959773,0.0007151925,0.0004881542,0.0004871048,0.0003868052,0.0005799212,0.0006663974,0.0005053289,0.001336734],"category_scores_gemma":[0.0005227069,0.0002569856,0.0004379036,0.0002750519,0.0004832826,0.0003994128,0.0004373071,0.0006266575,0.0006013148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007397566,"about_ca_system_score_gemma":0.001479841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00377209,"about_ca_topic_score_gemma":0.004783008,"domain_scores_codex":[0.999403,0.00006274547,0.00003909789,0.00009597131,0.0003248575,0.00007435953],"domain_scores_gemma":[0.9997324,0.00006460884,0.00005161348,0.00003947716,0.00007718947,0.00003464703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004764743,0.00005070534,0.00006361627,0.0000232184,0.000005019752,0.00003903257,0.000009972539,0.000462829,0.9968477,0.0002404719,0.00006013941,0.002149723],"study_design_scores_gemma":[0.00003315465,0.0005196421,0.0005820238,0.00000631159,0.000016299,0.00006971162,0.000009310852,0.002198303,0.9944316,0.00004766908,0.002077222,0.000008784966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8598739,0.0009568874,0.117746,0.001036856,0.0001898577,0.00299978,0.003712995,0.001093174,0.01239053],"genre_scores_gemma":[0.802467,0.002165387,0.1755601,0.0003110289,0.00002307325,0.001648555,0.002789589,0.0002463246,0.01478893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00377209,"threshold_uncertainty_score":0.007500231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03532468926532236,"score_gpt":0.3712347703089443,"score_spread":0.3359100810436219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}