{"id":"W7133041016","doi":"","title":"Investigating the Role of p53 in Cellular Stress Responses to Deregulated Anabolic Metabolism","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Anabolism; mTORC1; Cancer cell; Catabolism; Cancer; Cell growth; Crosstalk","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198513,0.000259968,0.0001379427,0.0002836153,0.0002262035,0.0003717462,0.0001628451,0.0002869602,0.002122691],"category_scores_gemma":[0.0001147193,0.00008313241,0.0002040922,0.000204824,0.0003062323,0.0003578211,0.000201854,0.0005232124,0.0004347562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489541,"about_ca_system_score_gemma":0.0004386686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004464328,"about_ca_topic_score_gemma":0.0005375909,"domain_scores_codex":[0.9999532,0.000006793658,0.000001875951,0.00001154447,0.00001050142,0.00001615767],"domain_scores_gemma":[0.9999503,0.00001088682,0.00001219605,0.00000407181,0.00001047781,0.00001214953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004638878,0.00009773848,0.0008077642,0.000244856,0.000009838446,0.0002421059,0.00007559951,0.0002691853,0.9646651,0.002498103,0.0003699205,0.03025585],"study_design_scores_gemma":[0.00006342596,0.001434904,0.02101664,0.0001055737,0.00004050765,0.0006167388,0.00026351,0.001311289,0.9490227,0.003315423,0.02279434,0.00001497582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9229826,0.04286248,0.009247879,0.002440736,0.0001646279,0.0001103158,0.0004351113,0.0001312802,0.02162497],"genre_scores_gemma":[0.9631124,0.02250287,0.002903358,0.0002162584,0.00007319575,0.00005767461,0.0002571377,0.00001603877,0.01086095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002122691,"threshold_uncertainty_score":0.007101119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147197220108752,"score_gpt":0.3127216225184577,"score_spread":0.3012496503173702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}