{"id":"W7133044667","doi":"","title":"ORP3 Promotes ALPK1-TIFA Dependent NF-κB Activation upon Detection of Bacterial Heptose Phosphate containing Metabolites","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"HEK 293 cells; Innate immune system; Transfection; Cytosol; Cell culture; Receptor; Signal transduction; Luciferase; Immune system; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007633433,0.0002398684,0.0001210825,0.0001036165,0.0001564483,0.000216724,0.0001269911,0.0001719323,0.003697556],"category_scores_gemma":[0.00005924904,0.00008495519,0.0002744345,0.0001001554,0.0001208571,0.0001140908,0.0002085536,0.0005670619,0.00136047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524858,"about_ca_system_score_gemma":0.0002513588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006899245,"about_ca_topic_score_gemma":0.001227068,"domain_scores_codex":[0.9999303,0.000006556085,0.000003911615,0.00001596326,0.00001834776,0.00002496021],"domain_scores_gemma":[0.9999642,0.000005615389,0.000008254991,0.000003127897,0.000005237608,0.00001353222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001217215,0.00002159663,0.00006956701,0.00002352655,0.000001256261,0.00003494741,0.00001147114,0.00002211032,0.9987088,0.00005397246,0.0001264756,0.0008044615],"study_design_scores_gemma":[0.00002470245,0.0001222834,0.004829791,0.00001370626,0.000005036269,0.000105137,0.00004915714,0.0004426329,0.99052,0.00009462049,0.003790021,0.00000287913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750621,0.002162531,0.006492068,0.0007423025,0.0001069209,0.00008718869,0.00155044,0.0002282968,0.01356813],"genre_scores_gemma":[0.9723685,0.001743879,0.003573955,0.0002651285,0.00002249425,0.0001145095,0.001640192,0.00006033957,0.02021098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003697556,"threshold_uncertainty_score":0.01236951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390717473379773,"score_gpt":0.2972257843630458,"score_spread":0.2833186096292481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}