{"id":"W7133053850","doi":"","title":"Myocardial Structure and Function in Heart Failure with Preserved Ejection Fraction: Molecular Insights and Therapeutic Strategies Targeting Transforming Growth Factor Beta Signaling","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; York University","keywords":"Heart failure; Heart failure with preserved ejection fraction; Diastole; Pressure overload; Fibrosis; Myocardial fibrosis; Blockade; Cardiac function curve; Pathophysiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002723786,0.0007582573,0.001121435,0.0005155661,0.0006918109,0.0003311455,0.00007166397,0.0006351992,0.000216725],"category_scores_gemma":[0.00002320081,0.0006662166,0.000233164,0.0006058823,0.00008149982,0.0005595508,0.00003233562,0.001791721,5.284983e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241665,"about_ca_system_score_gemma":0.0003861233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019934,"about_ca_topic_score_gemma":0.0002826758,"domain_scores_codex":[0.9966105,0.00035523,0.0006295968,0.001056779,0.000827278,0.0005205733],"domain_scores_gemma":[0.998843,0.0001422285,0.0003384473,0.0002399884,0.0002477162,0.0001885967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"qualitative","study_design_scores_codex":[0.002715823,0.00006006603,0.01440295,0.001900238,0.0008365738,0.0000186805,0.0187935,0.01091456,0.9492338,0.0001951954,0.000009201524,0.000919364],"study_design_scores_gemma":[0.01092898,0.004215989,0.1606265,0.004063956,0.005143886,0.0001725016,0.6228089,0.01640198,0.1677978,0.0009127374,0.003548343,0.00337837],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773477,0.01790714,0.002097758,0.0003042726,0.0006380665,0.001461667,0.00001640382,0.00006850653,0.0001585042],"genre_scores_gemma":[0.9975466,0.0006858265,0.0004630721,0.00006521215,0.0004307433,0.00005653017,0.0005627128,0.0001356567,0.00005371027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.781436,"threshold_uncertainty_score":0.9995789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072133345012717,"score_gpt":0.2681254411228076,"score_spread":0.2574041076726804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}