{"id":"W7133053850","doi":"","title":"Myocardial Structure and Function in Heart Failure with Preserved Ejection Fraction: Molecular Insights and Therapeutic Strategies Targeting Transforming Growth Factor Beta Signaling","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; York University","keywords":"Heart failure; Heart failure with preserved ejection fraction; Diastole; Pressure overload; Fibrosis; Myocardial fibrosis; Blockade; Cardiac function curve; Pathophysiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496413,0.0003620136,0.0003496085,0.0002620993,0.0001255445,0.0004028585,0.000256893,0.000331624,0.0009406485],"category_scores_gemma":[0.00006277518,0.0001112208,0.0002683884,0.0001170226,0.0002289168,0.0002687156,0.0001947118,0.001424748,0.0002350264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781681,"about_ca_system_score_gemma":0.0002918299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518196,"about_ca_topic_score_gemma":0.0004492285,"domain_scores_codex":[0.9999707,0.000004810159,0.000002082947,0.00000442007,0.000007030061,0.00001107359],"domain_scores_gemma":[0.9999694,0.000004116006,0.00001008171,0.000002323018,0.000004782794,0.000009251831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001024163,0.0008361267,0.0009991801,0.001500465,0.00008744288,0.0004520248,0.0001113199,0.0006537026,0.8406912,0.004597689,0.00293723,0.1461094],"study_design_scores_gemma":[0.002253319,0.01830177,0.06906856,0.001787787,0.001486354,0.006909083,0.0009906808,0.0102971,0.6000409,0.01160078,0.2771029,0.0001608208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4800011,0.479904,0.01672601,0.00942206,0.0009272693,0.000254539,0.0004827847,0.0003045823,0.01197768],"genre_scores_gemma":[0.7003462,0.2840502,0.008008065,0.001403704,0.0005466426,0.000182724,0.0004570935,0.000018372,0.004986966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009406485,"threshold_uncertainty_score":0.003146768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072133345012717,"score_gpt":0.2681254411228076,"score_spread":0.2574041076726804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}