{"id":"W7133057640","doi":"","title":"Understanding obstacles to retroviral mediated gene therapy of globin disorders: Implications for design of therapeutic expression cassettes and retrovirus vectors","year":2002,"lang":"","type":"dissertation","venue":"TSpace","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Hospital for Sick Children","keywords":"Locus control region; Gene silencing; Transgene; Chromatin; Genetic enhancement; Retrovirus; Enhancer; Gene; Vector (molecular biology); Vectors in gene therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003112165,0.001029046,0.001662593,0.0006403929,0.0007599689,0.003905781,0.00174649,0.002694802,0.001161646],"category_scores_gemma":[0.002114027,0.0009072406,0.0007522806,0.0004257851,0.002052019,0.004597795,0.001139205,0.006493463,0.00075994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003389532,"about_ca_system_score_gemma":0.002141919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120097,"about_ca_topic_score_gemma":0.00138616,"domain_scores_codex":[0.9989836,0.0002241958,0.000108638,0.0001446103,0.0003655018,0.000173575],"domain_scores_gemma":[0.9986303,0.0007612716,0.0002545795,0.00006318929,0.0001721121,0.0001186115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00052699,0.0006797055,0.005348613,0.004367562,0.0001134767,0.001723155,0.001072037,0.04340367,0.6357139,0.1883298,0.002468908,0.1162523],"study_design_scores_gemma":[0.0002391979,0.002220917,0.008439547,0.00191979,0.0004022029,0.00453807,0.003573688,0.07871679,0.4235007,0.313044,0.1630283,0.0003768084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2841741,0.2414419,0.4265104,0.03008677,0.0007826534,0.0007394849,0.0004638032,0.0005598446,0.015241],"genre_scores_gemma":[0.5434354,0.2415408,0.2006078,0.004398799,0.0005896893,0.001292898,0.0007838715,0.0001812517,0.007169571],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003905781,"threshold_uncertainty_score":0.02459294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.127754526787624,"score_gpt":0.3777833438137164,"score_spread":0.2500288170260924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}