{"id":"W7133061292","doi":"","title":"Discovery and Characterization of Small-molecule CRISPR/Cas13 Inhibitors Using a High Throughput Platform","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CRISPR; Palindrome; DNA; Gene; Genome editing; RNA; In vitro; Cell; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002715559,0.000479752,0.0005836755,0.0004841282,0.0001881977,0.0006398445,0.0004101508,0.0002845448,0.001949778],"category_scores_gemma":[0.0001882449,0.000244125,0.0004700867,0.0004392096,0.0001293044,0.0002745256,0.0001813756,0.0005952519,0.001118879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004827123,"about_ca_system_score_gemma":0.0005329994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008302907,"about_ca_topic_score_gemma":0.002166933,"domain_scores_codex":[0.9998305,0.00001603223,0.00001172242,0.00002673066,0.00009090797,0.00002406619],"domain_scores_gemma":[0.9999118,0.00001559512,0.00001849693,0.000006864303,0.0000297858,0.00001745456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001103445,0.0001905324,0.000203532,0.000168037,0.00003256859,0.00008577344,0.00002197194,0.001802903,0.9813982,0.0003122644,0.000565926,0.01510797],"study_design_scores_gemma":[0.00004356981,0.0007337915,0.0006412427,0.00001231457,0.00004418272,0.0001670953,0.000009992911,0.002101542,0.9900771,0.00004890814,0.006108507,0.0000118068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8842412,0.01850095,0.06679924,0.0005574605,0.0001202867,0.001302265,0.006881802,0.0009869405,0.02060997],"genre_scores_gemma":[0.8790923,0.0234179,0.05837843,0.0004125894,0.00003537905,0.0006685813,0.007781204,0.0001966803,0.0300168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949778,"threshold_uncertainty_score":0.006522715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642483763929631,"score_gpt":0.3272125192909326,"score_spread":0.3107876816516363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}