{"id":"W7133061373","doi":"","title":"Identifying tissue specific transcriptional regulatory elements in mammalian genomes","year":2021,"lang":"","type":"dissertation","venue":"TSpace","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Enhancer; DNA binding site; Transcription factor; Genome; Regulatory sequence; Gene; Conserved sequence; Regulation of gene expression; Enhancer RNAs; Epigenomics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673954,0.0002359432,0.000300382,0.0005671678,0.0003236413,0.0004897736,0.0003426559,0.0003897181,0.001534792],"category_scores_gemma":[0.0006598324,0.0002386293,0.0003439363,0.0009713151,0.0003084745,0.000378572,0.0003342467,0.0007025308,0.001165282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003252674,"about_ca_system_score_gemma":0.0003634696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009058391,"about_ca_topic_score_gemma":0.001072442,"domain_scores_codex":[0.9997951,0.00002051911,0.00001260729,0.0001164051,0.00003853311,0.00001680839],"domain_scores_gemma":[0.9998068,0.00006456997,0.00005354729,0.00002379142,0.00003686786,0.00001444959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002017126,0.00006995547,0.01384489,0.001232652,0.00004735203,0.0003752889,0.0005867168,0.00403549,0.7362304,0.0234251,0.003330399,0.2166201],"study_design_scores_gemma":[0.00005397075,0.0004708691,0.1613763,0.0006992735,0.000254736,0.002968879,0.001110867,0.02595113,0.4735127,0.05999407,0.273513,0.00009414184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5462589,0.0323559,0.3769807,0.001926784,0.0002403083,0.000332313,0.01518902,0.002219649,0.0244965],"genre_scores_gemma":[0.6394557,0.02086078,0.3109787,0.0009698857,0.0001635461,0.0002992739,0.01711878,0.0002409359,0.009912454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534792,"threshold_uncertainty_score":0.005134404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592791550134894,"score_gpt":0.2964080682457411,"score_spread":0.2804801527443922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}