{"id":"W7133062423","doi":"","title":"Exploring Phosphorylation-independent Pathway of STAT5 Activation for Development of Small Molecule Inhibitors of STAT5","year":2019,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"STAT5; Small molecule; Intracellular; Tyrosine kinase; SH2 domain; Protein tyrosine phosphatase; Phosphorylation; Tyrosine; Chromosomal translocation; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765733,0.0003165033,0.0001619555,0.0001983753,0.0001402031,0.0002027749,0.0001900632,0.0002592148,0.003593394],"category_scores_gemma":[0.00006976584,0.0001079845,0.0003315431,0.0001482622,0.0001112191,0.0001714721,0.0001248864,0.0006185386,0.0007527967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141383,"about_ca_system_score_gemma":0.000266715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002907496,"about_ca_topic_score_gemma":0.0009026233,"domain_scores_codex":[0.9999406,0.0000107608,0.000004016075,0.00001071198,0.0000170472,0.00001682232],"domain_scores_gemma":[0.9999774,0.000004325898,0.000005260098,0.000001522364,0.000005005969,0.000006596973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489628,0.0001531055,0.0001184152,0.0002141691,0.00001173223,0.00004606992,0.00002699265,0.0003644181,0.9845804,0.0006189075,0.0004880712,0.01322881],"study_design_scores_gemma":[0.0001492419,0.001531157,0.0018523,0.00004815651,0.0000532579,0.0002320073,0.00002732268,0.00170222,0.9724647,0.000226867,0.02170197,0.00001086954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8829257,0.05362242,0.02848657,0.002116999,0.0003441806,0.000833364,0.001852523,0.0002463398,0.02957197],"genre_scores_gemma":[0.9359666,0.0297388,0.01345236,0.000541107,0.00005236145,0.0002909709,0.001676784,0.00002962312,0.01825147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003593394,"threshold_uncertainty_score":0.01202106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1122484311096061,"score_gpt":0.3382666268619089,"score_spread":0.2260181957523028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}