{"id":"W7133064754","doi":"","title":"Interdependent toxicity mechanisms of oxidative stress, thiamin deficiency and alpha-oxoaldehydes","year":2006,"lang":"","type":"dissertation","venue":"TSpace","topic":"Alcoholism and Thiamine Deficiency","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Oxidative stress; Methylglyoxal; Glycation; Reactive oxygen species; Glyoxal; Oxidative phosphorylation; Glutathione; Antioxidant; Cytotoxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009967027,0.001143734,0.001736647,0.0006097879,0.0003370241,0.00008475423,0.0005465172,0.0007470111,0.0006062707],"category_scores_gemma":[0.0004143754,0.001039256,0.0003711303,0.0006249368,0.0004759368,0.000230429,0.0002665057,0.001011047,0.00007437232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178421,"about_ca_system_score_gemma":0.0003594578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002150321,"about_ca_topic_score_gemma":0.0006173112,"domain_scores_codex":[0.9945028,0.0003567066,0.001401369,0.00138632,0.001410542,0.0009423015],"domain_scores_gemma":[0.9964265,0.0003210797,0.001473789,0.0009149984,0.0005296151,0.0003340024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00297413,0.00696566,0.00645907,0.01489071,0.0009904092,0.0006655074,0.1226101,0.0001233048,0.7369637,0.08444703,0.002015534,0.02089483],"study_design_scores_gemma":[0.004307278,0.003686508,0.03300204,0.004013294,0.00234004,0.00009418769,0.1104969,0.0006927045,0.8359518,0.003723697,0.00009747039,0.001594076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9214762,0.008960767,0.01112713,0.0001812707,0.001214863,0.001520947,0.0002288342,0.00008923295,0.05520072],"genre_scores_gemma":[0.9807347,0.0009396064,0.001146756,0.00006286185,0.0001951478,0.00004245007,0.001252236,0.0001232299,0.01550301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09898806,"threshold_uncertainty_score":0.9992058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156613821124807,"score_gpt":0.3191371382124765,"score_spread":0.3034757560999958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}