{"id":"W7133070792","doi":"","title":"Targeting the TIGIT/CD226/CD96 Signaling Axis using the IgV Domain of PVR","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Receptor; Immune system; Signal transduction; Extracellular; TIGIT; Autoimmune disease; Domain (mathematical analysis); Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006484561,0.0002423128,0.0001045097,0.00007992634,0.00009262873,0.00025575,0.0001230769,0.000211888,0.001380252],"category_scores_gemma":[0.00003177505,0.00006318948,0.0002327798,0.00005906159,0.0001075342,0.0001237972,0.0001142478,0.0004957145,0.0005809266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003218385,"about_ca_system_score_gemma":0.0002487247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003160947,"about_ca_topic_score_gemma":0.000351882,"domain_scores_codex":[0.9999685,0.000003775126,0.000001556533,0.000007976576,0.000007330608,0.00001094756],"domain_scores_gemma":[0.999989,0.000001351235,0.000002672067,9.269656e-7,0.000001968821,0.000003983684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004251017,0.0000228447,0.00004861174,0.00004191186,0.000002459646,0.00002994865,0.00001172408,0.0001092088,0.9942611,0.0005281328,0.0001223466,0.004779138],"study_design_scores_gemma":[0.00001993879,0.0002523719,0.001107756,0.0000138904,0.000008055101,0.0001661243,0.00002264573,0.0006142435,0.9863499,0.0001720846,0.01127036,0.000002520092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.938327,0.01133382,0.02518621,0.001263931,0.0001711644,0.000161724,0.0004862523,0.000194274,0.02287566],"genre_scores_gemma":[0.9388407,0.007914861,0.0138643,0.0002287161,0.00004112473,0.0001172833,0.0006194212,0.00002965585,0.03834394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001380252,"threshold_uncertainty_score":0.004617453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556387868299837,"score_gpt":0.3140535699104969,"score_spread":0.2884896912274986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}