{"id":"W7133071972","doi":"","title":"System Wide Views of Proteome Abundance and Dynamic Localization Reveals Novel Saccharomyces cerevisiae Stress Response and Replication Checkpoint Pathways","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eidgenössische Technische Hochschule Zürich","keywords":"Saccharomyces cerevisiae; Proteome; Cellular stress response; Proteomics; Quantitative proteomics; Signal transduction; Protein kinase A; DNA replication; Kinase; Function (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005639085,0.0004741464,0.0005019131,0.001129017,0.0003526628,0.001075291,0.0002849738,0.0002906124,0.0007897452],"category_scores_gemma":[0.0006628212,0.0002288267,0.0006238121,0.001060339,0.0002420027,0.0006985691,0.0008011166,0.0004734899,0.000269994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005554972,"about_ca_system_score_gemma":0.0004116028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003713371,"about_ca_topic_score_gemma":0.004729703,"domain_scores_codex":[0.9997732,0.00003022621,0.00001141149,0.0001166397,0.00004148608,0.00002700225],"domain_scores_gemma":[0.9997664,0.00004530495,0.00005576447,0.0000417097,0.00005241481,0.00003840616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001718789,0.0002173792,0.2004686,0.001130563,0.001605636,0.001277555,0.00121035,0.03163901,0.674798,0.006091862,0.01210547,0.06773667],"study_design_scores_gemma":[0.00007066444,0.0002722127,0.6768665,0.00007536745,0.0005651712,0.0007379174,0.00123177,0.2227642,0.05892882,0.01558804,0.02276027,0.0001390385],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.938408,0.004773515,0.03813566,0.0004888939,0.00005992513,0.00004300131,0.01148332,0.002740607,0.003867169],"genre_scores_gemma":[0.9650805,0.001607198,0.01780665,0.0001365504,0.0000385102,0.00004904694,0.01454149,0.0002589328,0.0004811781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003713371,"threshold_uncertainty_score":0.007383525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146913348438943,"score_gpt":0.3317932553611626,"score_spread":0.3103241218767731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}