{"id":"W7133087432","doi":"","title":"The Role of Exosomes in Spreading Pathology in Synucleinopathies","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Microvesicles; Synucleinopathies; Dementia with Lewy bodies; Atrophy; Extracellular vesicles; Exosome; Alpha-synuclein; Biomarker; Extracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829169,0.0002149418,0.0001408603,0.0003012814,0.0003181475,0.0005866518,0.00007191627,0.0002794967,0.00161525],"category_scores_gemma":[0.0001849199,0.00007861281,0.0001430018,0.0001518868,0.0001780951,0.0003401744,0.000319979,0.000342552,0.0004248459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001685974,"about_ca_system_score_gemma":0.0002271551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001613609,"about_ca_topic_score_gemma":0.0002342749,"domain_scores_codex":[0.9999455,0.0000147651,0.000004263067,0.000009445787,0.00001596177,0.00001003083],"domain_scores_gemma":[0.9999211,0.000018534,0.00001046613,0.000004463799,0.00002177821,0.00002360848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008937314,0.000270638,0.003823076,0.0006756746,0.00003493658,0.001680661,0.0008703231,0.0003413373,0.8801076,0.007705383,0.002418899,0.1011778],"study_design_scores_gemma":[0.0002215881,0.002124853,0.131843,0.0007598544,0.0001415536,0.005674861,0.001716489,0.001814258,0.7016139,0.0111193,0.1429194,0.00005105327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8445207,0.1266203,0.003678619,0.001849814,0.0003729027,0.0001060566,0.0004423075,0.00006201609,0.02234733],"genre_scores_gemma":[0.9139607,0.05871937,0.002064515,0.0002305658,0.0001470489,0.00005757161,0.0003256989,0.00001585401,0.02447872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00161525,"threshold_uncertainty_score":0.005403578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076365485288371,"score_gpt":0.3115044430040046,"score_spread":0.3007407881511209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}