{"id":"W7133097859","doi":"","title":"Functional Analysis of the Contribution of HIF-1α Proline 402 to the Interaction with VHL","year":2016,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cycloheximide; Hydroxylation; Transcription factor; Ubiquitin; In vitro; Proline; Functional analysis; Transcription (linguistics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009445055,0.0002070306,0.0001036986,0.00009523393,0.0001580068,0.0001704026,0.0001606115,0.0001838324,0.001135451],"category_scores_gemma":[0.00007974727,0.00007132217,0.0001759109,0.0001489296,0.0001192619,0.000119766,0.00008816586,0.0002417566,0.0003580761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003233341,"about_ca_system_score_gemma":0.0001047252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009716931,"about_ca_topic_score_gemma":0.0005645577,"domain_scores_codex":[0.9999481,0.000007913813,0.000003226788,0.00001196906,0.00001198553,0.00001676326],"domain_scores_gemma":[0.9999483,0.00001164904,0.00001191085,0.000004086749,0.000006463848,0.00001765501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002690494,0.00001932109,0.000266046,0.00001902732,0.000003642627,0.00004826997,0.000006664729,0.00005434353,0.9986019,0.00007073209,0.00002722872,0.0006138033],"study_design_scores_gemma":[0.00001548386,0.0001448612,0.01092911,0.00000334581,0.00001236714,0.0004043171,0.00002388912,0.001316551,0.9845769,0.00005112819,0.002518548,0.000003513093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977537,0.0005275678,0.0006498908,0.00006307965,0.000009715905,0.000004775925,0.0003578012,0.000007867309,0.000625595],"genre_scores_gemma":[0.9944769,0.0005072581,0.0009020445,0.00003787357,0.00000702158,0.000008379904,0.001211299,0.00001137347,0.002837986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135451,"threshold_uncertainty_score":0.003798425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008037718358413487,"score_gpt":0.2900634385040344,"score_spread":0.2820257201456209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}