{"id":"W7134220698","doi":"","title":"Guiding principles for mixture threshold derivation from effect biomarkers","year":2025,"lang":"en","type":"report","venue":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Risk assessment; Biomarker; Stressor; Adverse effect; Exposure assessment; Biomonitoring; Adverse Outcome Pathway; Human health; Event (particle physics)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01641206,0.002586942,0.001801448,0.003914723,0.001518507,0.005870117,0.006140324,0.004382072,0.0109781],"category_scores_gemma":[0.03062205,0.00153665,0.003587818,0.002290727,0.004095613,0.00481629,0.00578372,0.006657576,0.009540884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002442881,"about_ca_system_score_gemma":0.005112264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004557126,"about_ca_topic_score_gemma":0.002799157,"domain_scores_codex":[0.992672,0.002328045,0.0005426701,0.001187604,0.002943621,0.0003260954],"domain_scores_gemma":[0.989922,0.00453518,0.000643675,0.001242131,0.003444075,0.0002128372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002139643,0.0002928751,0.002890648,0.001979091,0.0001833439,0.0009355197,0.0006524748,0.05035217,0.02208517,0.7577765,0.02033266,0.1423057],"study_design_scores_gemma":[0.00009199139,0.0002726062,0.001302817,0.0009701867,0.0001675726,0.0009515082,0.0002306347,0.1795733,0.02164246,0.6554685,0.1391277,0.0002007645],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.001086641,0.0008215852,0.9898673,0.001060464,0.0002392854,0.0002704785,0.0004579918,0.0004339128,0.005762248],"genre_scores_gemma":[0.04687855,0.00240862,0.9391143,0.001730841,0.0004766959,0.001587329,0.001233892,0.0006946281,0.005875153],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01641206,"threshold_uncertainty_score":0.08679634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1282688156218843,"score_gpt":0.4177630550847575,"score_spread":0.2894942394628732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}