{"id":"W7135019574","doi":"10.1093/neuped/wuaf001.184","title":"LGG-01. Managing side effects of MAPK inhibitor therapies in pediatric populations: a Delphi consensus initiative","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Pediatrics","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Adverse effect; Delphi method; Multidisciplinary approach; Clinical trial; MEDLINE; Trametinib; Delphi","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020793,0.0002591549,0.0005783415,0.001484387,0.00009216939,0.00001276697,0.0001351549,0.0002029825,0.000008530617],"category_scores_gemma":[0.001938204,0.0002420428,0.0001302806,0.00168185,0.0001342832,0.00006903262,0.0001494348,0.0005698068,0.00002514935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213785,"about_ca_system_score_gemma":0.0006277838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004576874,"about_ca_topic_score_gemma":0.00006400704,"domain_scores_codex":[0.9977237,0.0003989474,0.0005854626,0.0004512553,0.000343251,0.0004974117],"domain_scores_gemma":[0.9962345,0.002897412,0.0002193987,0.0003161127,0.0001819373,0.0001506442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001982385,0.00240286,0.9586105,0.002062725,0.0001413822,0.006646959,0.0009382209,0.0000582168,0.01076031,0.001312976,0.006131764,0.008951642],"study_design_scores_gemma":[0.01591329,0.003791065,0.9660208,0.0001150417,0.0008914113,0.0001258049,0.0003301931,0.0002759582,0.006058987,0.005130833,0.001003084,0.0003435289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989435,0.002470915,0.00004716074,0.00229501,0.0006606365,0.001306477,0.00001489463,0.00008159874,0.003688278],"genre_scores_gemma":[0.9954941,0.002065396,0.0008180556,0.001100264,0.0002712347,0.0001243075,0.00001880859,0.00003164311,0.00007620628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0139309,"threshold_uncertainty_score":0.9870219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916711786534238,"score_gpt":0.3356941828194258,"score_spread":0.3065270649540834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}