{"id":"W7135038057","doi":"10.1093/neuped/wuaf001.201","title":"MDB-01. Cerebrospinal fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Pediatrics","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Cerebrospinal fluid; Metastasis; Mechanosensitive channels; Medulloblastoma; GLUT1; Shear stress; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243695,0.0003018703,0.0002505907,0.0002019926,0.0002111867,0.0003278161,0.0001738825,0.0002882712,0.003465366],"category_scores_gemma":[0.0001026517,0.000148012,0.0002355049,0.0001202814,0.0002426073,0.0001640781,0.0002018471,0.000914037,0.0005867961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005253422,"about_ca_system_score_gemma":0.0006520691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241285,"about_ca_topic_score_gemma":0.002499954,"domain_scores_codex":[0.9998897,0.00001479425,0.000007757849,0.00001703823,0.00002855155,0.00004204306],"domain_scores_gemma":[0.9999387,0.000005122857,0.00001120485,0.000003332969,0.000005480212,0.0000361535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007801034,0.0003697921,0.0004841175,0.0001816384,0.00001559953,0.0001250517,0.0000234974,0.0002258057,0.9913914,0.0004912847,0.0009039629,0.005007748],"study_design_scores_gemma":[0.0004692392,0.002569905,0.01118605,0.00005880106,0.00003994071,0.0003999261,0.0001426405,0.002824473,0.9667975,0.000314194,0.01518191,0.0000154926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843493,0.004125233,0.002528763,0.001000063,0.0003010451,0.0001841126,0.001807527,0.000229308,0.005474521],"genre_scores_gemma":[0.9907956,0.001854959,0.001756694,0.0002339952,0.00002272106,0.0001801851,0.00100268,0.00001773448,0.004135577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003465366,"threshold_uncertainty_score":0.01159275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02002065974718749,"score_gpt":0.2956577266962195,"score_spread":0.2756370669490321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}