{"id":"W7135043269","doi":"10.1093/neuped/wuaf001.261","title":"OTHR-02. An international accelerator programme for novel brain tumour therapies: Early impact and lessons learned","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Pediatrics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Multidisciplinary approach; Identification (biology); Process (computing); Drug development; Clinical trial; Multidisciplinary team","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06057344,0.001014353,0.000780572,0.00129754,0.001660173,0.006283045,0.003228512,0.005344308,0.07346436],"category_scores_gemma":[0.0273216,0.0005304923,0.001401061,0.001091207,0.001688328,0.003195925,0.008129355,0.005657864,0.02989953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005142694,"about_ca_system_score_gemma":0.05279251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005565719,"about_ca_topic_score_gemma":0.006196533,"domain_scores_codex":[0.984,0.004540582,0.0005441016,0.0006745254,0.005883296,0.004357511],"domain_scores_gemma":[0.9494198,0.003814377,0.001966854,0.001785043,0.009607418,0.03340656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00213622,0.001264743,0.001735434,0.001279338,0.00003697714,0.0008227585,0.0007643984,0.0007361,0.003383826,0.0146561,0.6980202,0.2751639],"study_design_scores_gemma":[0.0006210242,0.002982386,0.005693496,0.001128512,0.00002671859,0.0005414877,0.000460644,0.000586132,0.001720763,0.002772958,0.9834141,0.00005169216],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03944904,0.04606058,0.02873891,0.3871338,0.08214717,0.0131026,0.0113809,0.006376551,0.3856105],"genre_scores_gemma":[0.1881337,0.03637036,0.07251077,0.08497483,0.0196408,0.008383891,0.02500666,0.004483734,0.5604952],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.07346436,"threshold_uncertainty_score":0.3203468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04080108542353954,"score_gpt":0.362662856176994,"score_spread":0.3218617707534544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}