{"id":"W7135081236","doi":"10.1093/neuped/wuaf001.225","title":"MDB-26. Omomyc is a promising anti-MYC therapy for pediatric medulloblastoma","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Pediatrics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences; Juravinski Cancer Centre","funders":"","keywords":"Medulloblastoma; Neurocognitive; Neural stem cell; Carcinogenesis; Clinical trial; Brain tumor; Regulator; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008149888,0.0002867568,0.0003199659,0.0002961962,0.0001258154,0.000226194,0.0002123671,0.0002573733,0.001769627],"category_scores_gemma":[0.00004447222,0.00007835827,0.0002335655,0.0001548583,0.0001064913,0.0001334943,0.000163506,0.0006553053,0.0003276096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342037,"about_ca_system_score_gemma":0.0002450454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006279941,"about_ca_topic_score_gemma":0.00191083,"domain_scores_codex":[0.9999655,0.000005662343,0.000003126512,0.000006686342,0.000008307822,0.00001066327],"domain_scores_gemma":[0.9999771,0.000002236776,0.000005977331,0.00000161298,0.000002314938,0.00001086365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003687398,0.001653324,0.002091523,0.0009017835,0.0001005572,0.0007932979,0.00005436646,0.001302958,0.8255727,0.0009885613,0.003327035,0.1595265],"study_design_scores_gemma":[0.001870537,0.02567513,0.04009311,0.000204299,0.0003307824,0.005318736,0.000139612,0.004137589,0.8036998,0.000564648,0.1179135,0.00005221201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288269,0.05378048,0.004647445,0.0007955681,0.0002843492,0.0004131507,0.001989284,0.0004077319,0.008855074],"genre_scores_gemma":[0.9746751,0.01508961,0.003840422,0.0002845332,0.00004135452,0.0001344614,0.001820014,0.00002216432,0.004092396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001769627,"threshold_uncertainty_score":0.005919993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149935278569719,"score_gpt":0.2860640474973927,"score_spread":0.2745646947116955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}