{"id":"W7135098097","doi":"10.1093/neuped/wuaf001.230","title":"MDB-31. The eEF2 kinase supports MYC-driven medulloblastoma metabolic adaptation to nutrient deprivation","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Pediatrics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Canada's Michael Smith Genome Sciences Centre; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Glutamine; Oxidative phosphorylation; Oxidative stress; Programmed cell death; Kinase; Glycolysis; Mitochondrion; Reactive oxygen species; Viability assay","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374992,0.00028967,0.0003036949,0.0002056914,0.0001759996,0.0002678723,0.0002573907,0.0002168955,0.001127155],"category_scores_gemma":[0.0001106365,0.000125188,0.0002027508,0.0001626256,0.0001811799,0.0001321944,0.0002153576,0.0004960842,0.0004035123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003534775,"about_ca_system_score_gemma":0.0003188423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652522,"about_ca_topic_score_gemma":0.002963287,"domain_scores_codex":[0.9998503,0.00001795827,0.00002125602,0.00002394823,0.00004122589,0.00004534406],"domain_scores_gemma":[0.9998753,0.00001340751,0.00002821391,0.00001442846,0.00001000221,0.00005861796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003400459,0.00009512398,0.0004948285,0.00002479205,0.00000451131,0.0000595571,0.00001117608,0.0000724377,0.9978897,0.00006102629,0.00009068314,0.0008561012],"study_design_scores_gemma":[0.00004524147,0.0006296003,0.01018324,0.000007300656,0.00001499309,0.0002982309,0.000056478,0.001713426,0.9838871,0.0000352428,0.003123843,0.000005102841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968125,0.0004324549,0.0009315597,0.0001002764,0.00002922914,0.00002903153,0.0008495771,0.00005953129,0.0007558526],"genre_scores_gemma":[0.994672,0.0002875967,0.001076039,0.0000371252,0.000004908143,0.00004825126,0.001570004,0.00002030686,0.00228373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001652522,"threshold_uncertainty_score":0.003770709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009125159953292262,"score_gpt":0.261374907403046,"score_spread":0.2522497474497538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}