{"id":"W7135918300","doi":"","title":"Developmental dysregulation of the cortical reelin signalling pathway precedes adolescent cognitive deficits in a neurodevelopmental model for schizophrenia","year":2023,"lang":"en","type":"article","venue":"Research Explorer (The University of Manchester)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; NIHR Imperial Biomedical Research Centre; National Institute of Mental Health; Science and Technology Facilities Council; Engineering and Physical Sciences Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; H. Lundbeck A/S; Universidade Federal do Rio Grande do Sul; Krembil Foundation; U.S. Public Health Service; Hospital de Clínicas de Porto Alegre; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; AXA Research Fund; Imperial College Healthcare NHS Trust; Wellcome Trust; University College London; George Washington University; King's College London; Medical Research Council; Israel Cancer Research Fund; Department of Health and Social Care; National Institute for Health and Care Research; Instituto D'Or de Pesquisa e Ensino; Royal Holloway, University of London; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; Rosetrees Trust; Research for Patient Benefit Programme; National Alliance for Research on Schizophrenia and Depression; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; South London and Maudsley NHS Foundation Trust; Directorate for Biological Sciences; Imperial College London; GlaxoSmithKline; Menzies Centre for Australian Studies, King's College London, University of London; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Jacobs Foundation; Dell EMC; Leverhulme Trust; Foundation for Excellence in Mental Health Care; University College London Hospitals NHS Foundation Trust; Johns Hopkins University; Pfizer; National Science Foundation","keywords":"Schizophrenia (object-oriented programming); Cognition; Reelin; Signalling; Neurodevelopmental disorder; Psychosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905708,0.0005511188,0.0003603002,0.0007034869,0.0003312606,0.0004603939,0.0002820903,0.0004382739,0.001836203],"category_scores_gemma":[0.0003864624,0.000205534,0.000304944,0.0001586232,0.0008799902,0.0002888542,0.000485213,0.0008668941,0.0001914658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006050735,"about_ca_system_score_gemma":0.0009206526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00568027,"about_ca_topic_score_gemma":0.008393957,"domain_scores_codex":[0.99991,0.00001665765,0.000008862804,0.00001878449,0.00002235906,0.00002329255],"domain_scores_gemma":[0.9996341,0.00005291153,0.0001706385,0.00002315004,0.00002770414,0.0000914538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003140951,0.0006401063,0.0400918,0.0002045385,0.00009058625,0.01007496,0.0007644815,0.0006797297,0.9311748,0.002743505,0.0004815739,0.009912978],"study_design_scores_gemma":[0.0001954084,0.002479766,0.7392316,0.0002422116,0.000278042,0.01398536,0.002074841,0.002802609,0.2323797,0.00283077,0.003433653,0.00006599605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983919,0.0002888033,0.0004200879,0.0001183001,0.00001150548,0.00001258269,0.0001769473,0.00002043329,0.0005593673],"genre_scores_gemma":[0.997908,0.0005610253,0.000433016,0.00003869506,0.000003248083,0.00001726579,0.0001300066,0.000009225464,0.000899528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00568027,"threshold_uncertainty_score":0.01129442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1890607497276372,"score_gpt":0.301586894534825,"score_spread":0.1125261448071878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}