{"id":"W7136087135","doi":"10.1183/13993003/erj.42.suppl_57.p655","title":"PBI-compound, a novel first-in-class anti-inflammatory/fibrotic compound, reduces bleomycin-induced idiopathic pulmonary fibrosis by regulation of extracellular matrix remodelling","year":2013,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Bleomycin; Extracellular matrix; Masson's trichrome stain; Fibrosis; Lung; Pulmonary fibrosis; Idiopathic pulmonary fibrosis; Elastin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008707507,0.0004819811,0.0004322471,0.0004409386,0.0001851214,0.0001877172,0.0002687228,0.0002442966,0.00262967],"category_scores_gemma":[0.00005870177,0.0001116615,0.0002567228,0.0001876691,0.0002326697,0.0001839473,0.0001516155,0.0007336047,0.0005971222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006805,"about_ca_system_score_gemma":0.0003740746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003571143,"about_ca_topic_score_gemma":0.0009728618,"domain_scores_codex":[0.9999558,0.000004819335,0.000002860349,0.000008953851,0.0000132312,0.00001431048],"domain_scores_gemma":[0.9999461,0.000004683875,0.00001702074,0.000002939562,0.000009055662,0.00002014334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008876273,0.0004388224,0.0004852836,0.0005699998,0.00003480961,0.0002208553,0.00001825323,0.0003296039,0.9783252,0.0002132022,0.0006091103,0.01786729],"study_design_scores_gemma":[0.0007444206,0.00815612,0.01116792,0.00006637796,0.0001458441,0.001521835,0.0000277779,0.001004044,0.9594247,0.0001256079,0.01758783,0.00002756704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458624,0.03190184,0.008016905,0.0007149114,0.0002657106,0.0004355593,0.002226245,0.0005988566,0.009977542],"genre_scores_gemma":[0.9610503,0.02066916,0.0083063,0.0003590817,0.000121827,0.0002249786,0.002528843,0.00004691428,0.006692736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00262967,"threshold_uncertainty_score":0.008797109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874072294364675,"score_gpt":0.2422701012957283,"score_spread":0.2235293783520815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}