{"id":"W7139457970","doi":"","title":"Development and Applications of Mitochondria-Penetrating Peptide Conjugates in Glioblastoma Multiforme","year":2025,"lang":"","type":"dissertation","venue":"TSpace (University of Toronto)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Temozolomide; Glioblastoma; Cytotoxicity; In vivo; Mitochondrion; Drug delivery; Downregulation and upregulation; U87; Cancer cell; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422645,0.000323841,0.0001908206,0.0001827982,0.0001129257,0.0002681561,0.0001358644,0.0003696437,0.0003744449],"category_scores_gemma":[0.0000955065,0.0001358437,0.0001963488,0.0001246581,0.0001145867,0.0001798909,0.0001855268,0.0002911568,0.0001991051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000316004,"about_ca_system_score_gemma":0.0001835247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005372316,"about_ca_topic_score_gemma":0.0006547107,"domain_scores_codex":[0.9999577,0.00000705747,0.000002451136,0.00001004058,0.00001430439,0.000008452116],"domain_scores_gemma":[0.9999717,0.000003744317,0.00001028435,0.000002015835,0.000005969124,0.000006313551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004886651,0.0000256248,0.00006974622,0.00008833329,0.000003852096,0.00007756861,0.00002399842,0.0003389313,0.9940905,0.0001590451,0.00005941512,0.005014172],"study_design_scores_gemma":[0.00002777847,0.001843401,0.001174907,0.00001797865,0.00002617055,0.0003880959,0.0000253264,0.001288675,0.9870733,0.00008779721,0.008035991,0.00001058474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811844,0.007756634,0.007969916,0.0002128734,0.00005042243,0.0001457087,0.0001542113,0.00009812853,0.002427633],"genre_scores_gemma":[0.9805831,0.007297836,0.009515419,0.00009937232,0.00001568309,0.00008164327,0.0001772634,0.00001892117,0.002210803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005372316,"threshold_uncertainty_score":0.002292812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008451391802480319,"score_gpt":0.2386876068981105,"score_spread":0.2302362150956302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}