{"id":"W7139714965","doi":"","title":"Studies of Microsatellite Instability Signatures in Replication Repair Deficient Malignant and Germline Tissues","year":2025,"lang":"","type":"dissertation","venue":"TSpace (University of Toronto)","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Microsatellite instability; DNA mismatch repair; Germline; Genome instability; Germline mutation; Microsatellite; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885312,0.0001486246,0.0001233336,0.001107622,0.0001489619,0.0003131047,0.0001292173,0.0002237265,0.000810129],"category_scores_gemma":[0.000361213,0.0001365999,0.0001562067,0.0004357444,0.0001292774,0.0001283745,0.0001824501,0.0002580659,0.0003774094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499728,"about_ca_system_score_gemma":0.0001163322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004545422,"about_ca_topic_score_gemma":0.0006915251,"domain_scores_codex":[0.9998556,0.00001341127,0.00001231825,0.00005245154,0.0000457865,0.00002047457],"domain_scores_gemma":[0.9996721,0.00004746641,0.0001234558,0.00002486805,0.00008579759,0.00004632972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001084873,0.00001412267,0.01471384,0.00008062451,0.00001565278,0.0001759589,0.0001485315,0.00006730875,0.9765156,0.0001273849,0.00007547797,0.007957115],"study_design_scores_gemma":[0.000007160842,0.000541079,0.1866977,0.00003139981,0.00007406709,0.003480677,0.0002800036,0.001238183,0.8011222,0.0002953096,0.006206088,0.00002614475],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876184,0.002255718,0.007267355,0.0000519954,0.00001926281,0.00003328058,0.001111464,0.0001441037,0.001498231],"genre_scores_gemma":[0.987569,0.001384174,0.006981457,0.00005497325,0.000009411973,0.00005513453,0.001361972,0.00002945299,0.002554298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107622,"threshold_uncertainty_score":0.002710104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519493273433734,"score_gpt":0.3133268576206669,"score_spread":0.2881319248863296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}